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Combigan (Brimonidine/Timolol)

TypeDrug NameDosage 
Combigan0.2 %/0.5 %/10 ml

Generic Equivalent of Combigan

No generic equivalents of Combigan found.


Is A Prescription Required To Purchase Combigan?

A Prescription is necessary to acquire Combigan at

What Is Combigan Used for?

Combigan is an ophthalmic solution (eye drops) used to treat open angle glaucoma or ocular hypertension (high pressure in the eye). Combigan helps by reducing the intraocular pressure. High pressure inside the eye can result in damage to the eye sight.

How Does Combigan Work?

The eye contains a clear watery liquid which is continuously drained out of the eye and replaced by new fluid. In glaucoma or ocular hypertension, the liquid is not able to drain quickly out of the eye, causing pressure to build up in the eye. Combigan (a fixed combination of brimonidine tartrate 0.2% and timolol 0.5% as timolol maleate) is a preserved eye solution, that helps to decrease the ocular pressure by reducing the amount of fluid entering the eye and increasing the amount of fluid draining out of the eye.

How Long Does It Take for Combigan to Work?

Both the ingredients of Combigan have a rapid onset of action, with peak effect occurring after 1 to 2 hours after administration. The duration of effect is longer than 12 hours.

How Is Combigan Supplied and Stored?

Combigan is a product of Allergan Canada. It is only available in strength of 0.2%/0.5%. Currently there are no generics available for Combigan. It is supplied in opaque and white plastic dropper bottles in quantities of 1, 2, 3 packs in 10 mL of eye drop solution.

The medicinal solution should be stored at a room temperature (15-25 °C), protected from light. It should be kept out of reach of children.

What Is the Cost of Combigan?

The cost of Combigan is mostly covered by medical insurance. The lower online pharmacy cost of $168 and the average retail price of $206 for the most common form of Combigan. However, our verified online Canadian pharmacy is pleased to offer Combigan at the cheapest price of $93 per bottle from Canada. It is always a good idea to compare the prices of Combigan from licensed online pharmacies on edrugsearch or

How Is Combigan Drop Used?

The normal dose of Combigan is one drop in the affected eye twice daily (morning and evening). However, it should be used exactly as prescribed by your health care professional as he/she is more aware of your condition.

In case you have to use Combigan with any other eye drop, the drops should be instilled in the eye at a gap of 10 minutes. Do not let the tip of the dropper to touch your eye or any of the areas around the eye in order to prevent eye injury and contamination of eye solution. Touching the dropper with other areas might lead to contamination of the eye solution which can cause serious eye infection.

How Is Combigan Metabolized?

Both the ingredients of Combigan (brimonidine tartrate and timolol maleate) are mainly metabolized by liver.

What Are the Side Effects of Brimonidine Tartrate Ophthalmic Solution?

Some of the common side effects of Combigan are burning/stinging sensation in the eye, dry mouth, itchiness, dryness, swelling and pain in the eye, blurring of vision and headache. If these side effects continue to persist, contact your health care professional. Some uncommon side effects include severe allergic reaction such as swelling of mouth and throat, slow or irregular heartbeat, low blood pressure, worsening of asthma, difficulty in breathing and low sugar levels in blood. These are not all the side effects due to Combigan. If you experience any unexpected side effect while using Combigan, please contact your doctor right away.

When Should You Not Take Combigan?

Do not take Combigan if you:
  • Are allergic to any of its ingredients
  • Have any respiratory disorders like asthma or chronic obstructive lung disease (COPD)
  • Have diabetes or low blood sugar levels due to no apparent reason
  • Have heart problems
  • Are taking Monoamine Oxidase Inhibitors (MOAIs) used to treat depression
  • Are pregnant or breast-feeding
The eye drop solution should not be used in children under the age of 2 years.

What Should You Tell Your Doctor Before Using Combigan?

Timolol (one of the ingredients of Combigan) has been reported to cause severe respiratory and cardiac reactions, including death because of bronchospasm in asthmatic patients and rarely because of cardiac failure. Before using Combigan you should talk to your health care professional if you:
  • Have a history of kidney or liver problems
  • Have a history of thyroid problems
  • Had eye problems in the past such as choroidal detachment
  • Have a history of problems associated with blood flow to brain
  • Have any history of lung problems especially asthma or heart problems
  • Have diabetes or have low blood sugar without any apparent reason
  • Have myasthenia gravis or any of its symptoms like general weakness, double vision or droopy eyelid
  • Experience depression
  • Are pregnant or planning a pregnancy
  • Are breast-feeding
  • Are planning to have any major surgery. If you need to take anesthesia during surgery, you must inform your anesthetist before surgery that you are using Combigan
  • If you have ocular surgery or develop an ocular condition such as trauma or infection in eye, immediately contact your health care professional about further use of Combigan from the multi-dose container
  • Are allergic to any of the ingredients or components of its container
  • Are taking any other prescription or non-prescription drugs, especially medicines that are used to lower blood pressure or treat other heart diseases
  • Wear contact lenses. This is because the preservative in Combigan (benzalkonium chloride) may get absorbed and change the color of lenses. Lenses should be removed prior to the use of Combigan and kept out 15 minutes after its use.
  • Drive or operate any heavy equipment. This drug might lead to fatigue or drowsiness in some patients or cause blurring of vision.

What Other Medicines Can Affect Combigan?

It is important that you tell your health care professional about all the prescription and non-prescription medications, vitamins and supplements you have been taking. Combigan and other medications can affect each other’s actions. Always confirm with your doctor before starting or stopping any medicines. Especially tell your doctor if you are taking any of the following:
  • Heart or other blood pressure medications such as beta-blockers, calcium channel blockers
  • Catecholamine depleting drugs such as resperine, epinephrine, quinidine, clonidine, tricyclic antidepressants
  • Alcohol
  • Central nervous system depressing drugs
  • Anti-arrhythmics such as amiodarone
  • Guanethidine and digitalis glycosides

Where Can I Buy Combigan Online?

If you have been prescribed Combigan by your health care professional, you can buy it directly from Canadian Online Pharmacy. The quick shipping service will not make you wait for the start of your therapy.

How Is Combigan Delivered?

The standard delivery fee is $10.00. The orders are usually shipped in 2-3 working days after the processing of the order. The medication package is delivered by regular mail within 10-14 business days after it has been shipped.

For further information and aid, you can contact our Customer Service at 604-581-4000 or email us at

  • Mailing Address:
  • Canada Wide Pharmacy
  • 102-15129 100 Avenue
  • Surrey, BC, V3R 9P4
  • order by phone 604-581-4000
  • Pharmacist: Yasir Mohamed
  • Pharmacy Hours:
  • Weekdays: 9:00AM - 5:00PM
  • Weekends: Closed